Antigenic mapping reveals sites of vulnerability on α-HCoV spike proteinArticle Published on 2022-11-042022-11-15 Journal: Communications Biology [Category] SARS, 진단, [키워드] antigenic appear characterized conserved distal domain dominant effective epitope Epitopes feasibility HCoV-229E HCoV-NL63 highlight human coronavirus imperative N-terminal domain Neutralizing neutralizing antibody panel of antibody Protein RBD Receptor binding domain receptor binding site recognize representing reveal S protein S proteins similarity spike Spike protein subset the SARS-CoV-2 understanding Vaccine design Vaccine development [DOI] 10.1038/s42003-022-04160-8 PMC 바로가기
More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitroArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 치료법, 치료제, [키워드] ACE2 receptor Analysis Antiviral antiviral genes antiviral response antiviral therapy can be used Cell cell line cells Combination competent Complete coronavirus Coronavirus replication CXCL10 cytidylic acid double-stranded expand fibroblast Gene Expression HCoV-229E HCoV-NL63 help Human human coronavirus human coronaviruses human lung IFN IFNs IFNβ in vitro increase in inducer Infection inhibit innate immune interferons ISG15 limit MERS-CoV Nanoparticles Pathogens Poly I:C. post infection PROTECT provided required SARS-CoV-2 SARS-CoV-2 pandemic stimulate translated Treatment Type I IFN type I interferon virus production were infected while [DOI] 10.1016/j.virusres.2022.198925 PMC 바로가기
Potential intestinal infection and faecal-oral transmission of human coronavirusesArticle Published on 2022-11-012022-11-15 Journal: Reviews in Medical Virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome circulating close contact common cold coronavirus coronavirus disease COVID-19 described detectable develop Evidence faecal-oral transmission highlight Human human coronavirus human coronaviruses in vitro in vivo Infection intestinal intestinal infection. manifestation MERS MERS-CoV Middle East occur Occurrence Patient Potential proportion provided Respiratory disease respiratory droplet SARS-CoV SARS-CoV-2 shown Spread Symptoms syndrome Transmission Viral RNA [DOI] 10.1002/rmv.2363 PMC 바로가기
SARS-CoV-2 Omicron variant is attenuated for replication in a polarized human lung epithelial cell modelArticle Published on 2022-10-272022-11-16 Journal: Communications Biology [Category] COVID19(2023년), SARS, 변종, [키워드] Air-liquid interface Analysis assessment Cell Culture D614G Delta Epidemic epidemiological epithelial Health human coronavirus human lung immortalized Infection Lower respiratory tract omicron pathogenicity reduced Replication respiratory virus risk SARS-CoV-2 Seasonal influenza significantly variant variants variants of concern virus virus infection [DOI] 10.1038/s42003-022-04068-3 PMC 바로가기
Multiplex PCR Detection of Respiratory Tract Infections in SARS-CoV-2-Negative Patients Admitted to the Emergency Department: an International Multicenter Study during the COVID-19 PandemicArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome Adults age age and sex association Bacterial caused Characteristics children circulating coronavirus coronavirus disease country COVID-19 COVID-19 pandemic detect detection determine diagnostic Emergency emergency department etiological agent Europe Evidence hospital human coronavirus Human rhinovirus Infection Intervention logistic regression model métapneumovirus Middle East multicenter study Multiplex PCR multiplex PCR assay Nasopharyngeal swab pandemic Panel pathogen Patient PCR prevalent respiratory respiratory pathogen respiratory syncytial virus respiratory tract respiratory tract infection respiratory viruses SARS-CoV-2 significantly higher Stratification Symptom symptomatic Symptoms target targets tested tract utility variety viral infection Viral infection. viruses [DOI] 10.1128/spectrum.02368-22 PMC 바로가기
SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared with SARS-CoV-2 mRNA vaccinationsArticle Published on 2022-10-182022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome antibodies antibody antigenic assays boost coronavirus CP: Immunology cross-react determine elicit Health care worker human coronavirus human coronaviruses Infection magnitude mRNA mRNA vaccination mRNA vaccines original antigenic sin. participant proportion reactive responses SARS-CoV-2 SARS-COV-2 infection specificity vaccination [DOI] 10.1016/j.celrep.2022.111496 PMC 바로가기
Design, Synthesis and In Vitro Evaluation of Spirooxindole-Based Phenylsulfonyl Moiety as a Candidate Anti-SAR-CoV-2 and MERS-CoV-2 with the Implementation of Combination StudiesArticle Published on 2022-10-062022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] accompanied ADMET anti-coronavirus activity anti-SARS-CoV-2 anti-SARS-CoV-2 therapeutics Anti-viral antiviral activity approach binding candidate Combination Community Compound COVID-19 drug combination drug combination protocol effective highlight highly pathogenic human coronavirus in silico inhibit investigated MD simulation MERS-CoV moiety molecular molecular dynamic simulation (MDS) pharmacophores protocol protocols reaction Research SARS-CoV-2 spirooxindole. synergistic synthesis tested were assessed [DOI] 10.3390/ijms231911861 PMC 바로가기
Multiplex Detection of Antibody Landscapes to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)/Influenza/Common Human Coronaviruses Following Vaccination or Infection With SARS-CoV-2 and InfluenzaArticle Published on 2022-10-032022-11-15 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory illness acute respiratory syndrome Adsorption analyzed antibody antibody immunity antibody landscape Antibody Response ARI Clinical presentations collected common human coronaviruses coronavirus coronavirus 2 cross-reactive antibody detection exhibited Human human coronavirus human coronaviruses in-depth analysis individual Infection Influenza influenza infection influenza vaccine influenza virus landscape Last multiplex multiplex detection. no interaction protective immunity public health threat representing respiratory respiratory infection response responses SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 vaccination Sensitivity and specificity sera serological evidence serum Spike protein vaccination Vaccine [DOI] 10.1093/cid/ciac472 PMC 바로가기
Human coronaviruses: The emergence of SARS-CoV-2 and management of COVID-19Review article Published on 2022-10-012022-10-05 Journal: Virus research [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, 치료기술, 치료제, [키워드] acute respiratory syndrome circumvent coronavirus coronavirus disease COVID-19 Cross-species transmission deaths disease severity global pandemic Healthcare system highlight Human human coronavirus human coronaviruses implication Infection Long COVID management Mutation Respiratory pathogens SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Seven Strains transmission of SARS-CoV-2 Treatment Vaccines variants of concern zoonotic transmission [DOI] 10.1016/j.virusres.2022.198882 [Article Type] Review article
AuNP-based biosensors for the diagnosis of pathogenic human coronaviruses: COVID-19 pandemic developmentsArticle Published on 2022-10-012022-11-15 Journal: Analytical and bioanalytical chemistry [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy Antigen Asymptomatic carrier AuNP AuNPs biofluid Biomarker CoV COVID-19 epidemic COVID-19 pandemic CoVs CRISPR Diagnosis Diagnostic method Early detection example gold helping higher risk highlight highly pathogenic CoV Human human coronavirus human coronaviruses identify Laboratory MERS-CoV nanobiosensors nucleic acids optical outbreak pathogenic Pathogenic. platform point-of-care Probability Protein provided RT-PCR SARS-CoV-1 SARS-CoV-2 Spread the disease the SARS-CoV-2 Transmission treatment intervention virus viruses [DOI] 10.1007/s00216-022-04193-2 PMC 바로가기